Rx: Reasons for Choosing PNx for your Healthcare Communications Needs
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Experience:
Project Areas | Therapeutic
Areas | Audiences | Results
Preclinical Publications and Abstracts
1. Bounameaux Y, Coffey JW, O-Donnell M, Kling K, Quinn RJ, Schoenholzer P, Szente A, Tobias LD, Tschopp T, et al. Synthesis of stereoisomeric pinane thromboxane derivatives and evaluation of the compounds as platelet aggregation inhibitors. Helv Chim Acta. 1983;66:989-1008.
2. Greene PH, Poonian MS, Nussbaum AL, et al. Restriction and modification of a self-complementary octanucleotide containing the EcoRI substrate. J Mol Biol. 1975;99(2):237-261.
3. Hamilton JG, Tobias LD. Thin-layer chromatographic separation of platelet enzyme reaction products of arachidonic acid. Prostaglandins. 1977;13(6):1019.
4. Poonian MS, Nowoswiat EF, Tobias L, Nussbaum AL. Chemical synthesis of a tetradecamer in the Dna series. Biorg Chem. 1973;2(4):322-336.
5. Tilley JW, Levitan P, Lind J, et al. N-(heterocyclic alkyl)pyrido[2,1-b]quinazoline-8-carboxamides as orally active antiallergy agents. J Med Chem. 1987;30(1):185-193.
6. Tobias LD, Batula CJ, Gilman N, Hamilton JG, Coffey J. Time-dependent inhibition of cyclooxygenase and n-8 lipoxygenase by diynoic fatty acids. Fed Proc. 1981;40(6):Abstract 1712.
7. Tobias LD, Hamilton JG. Inhibition of arachidonate metabolism by selected compounds in vitro with particular emphasis on the thromboxane A-2 synthase pathway. In Samuelsson B, Ramwell PW, Paoletti R, eds. Advances in: Prostaglandin and Thromboxane Research, Vol. 6. 4th International Prostaglandin Conference, Washington, D.C., USA, May 28-31, 1979. New York, NY: Raven Press; 1980:453-456.
8. Tobias LD, Hamilton JG. The effect of 5,8,11,14-eicosatetraynoic acid on lipid metabolism. Lipids. 1979;14(2):181-193.
9. Tobias LD, Hamilton JG, Dewhirst FE. Inhibition of human platelet lipoxygenase and sheep seminal vesicular cyclooxygenase by a series of substituted phenols and naphthols. Fed Proc. 1982;41(4):Abstract 4722.
10. Tobias L, Paulsrud JR. Chromatography of prostaglandins utilizing silicic acid impregnated-glass fiber sheets. Prostaglandins. 1975;9(1):57-60.
11. Tobias LD, Vane FM, Paulsrud JR. The biosynthesis of 1a, 1b-dihomo-PGF2 and 1a,1b-dihomo-PGF2 alpha from 7, 10, 13, 16-docosatetraenoic acid by an acetone-pentane powder of sheep vesicular gland microsomes. Prostaglandins. 1975;10(3):443-468.
12. Welton AF, Tobias LD, Fiedler-Nagy C, et al. Effect of flavonoids on arachidonic acid metabolism. Prog Clin Biol Res.1986;213:231-242.
13. Welton AF, Hope WC, Tobias LD, et al. Inhibition of antigen-induced histamine release and thromboxane synthase by FPL 55712, a specific SRA-A antagonist? Biochem Pharmacol.1981;30(11):1378-1382.
14. Welton AF, Tobias LD, Fiedler-Nagy C, Anderson W, Hope W, Meyers K, Coffey JW. Effect of flavonoids on arachidonic-acid metabolism. In Cody V, Middleton, E Jr, Harborne JB, eds. Progress in Clinical and Biological Research, Vol. 213. Plant Flavonoids in Biology and Medicine: Biochemical, Pharmacological, and Structure-Activity Relationships; Symposium, Buffalo, N.Y., USA, July 22-26, 1985. New York, NY: Alan R. Liss, Inc; 1986:231-242.
PATENTS
1. Method of reducing weight in obese mammals by oral administration of imidazole compounds as thromboxane synthetase inhibitors.
Patent assignee: Hoffmann-La Roche AG. Inventors: Hamilton JG; Sullivan AC; Tobias LD; Triscari J.
Patent Number (US) 4500540
2. Obesity treatment and lowering of insulin levels using thromboxane synthesis inhibitor compounds. e.g. imidazole, pyridine, pyrimidine or indole derivs.
Patent assignee: Hoffmann-La Roche AG
Inventors: Hamilton JG; Lands WEM; Tobias LD; Triscari J.
Patent Number (European) 28410
Patent Number Equivalents in other countries: (Netherlands) 8005946;
(South Africa) 8006531; (West Germany) 3041090, 3072035; (Japan) 56097267;
(United States) 4591594, 4731363.
